Synergistic effects of growth factors drive an RA phenotype in fibroblast-like synoviocytes
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چکیده
منابع مشابه
RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro.
Ligands for the receptor for advanced glycation endproducts (RAGE) are increased in RA synovial fluid (SF), serum and synovium. Since RAGE is present on fibroblast-like synoviocytes (FLS), the present study investigates whether the RAGE ligands HMGB-1 and AGEs are able to stimulate the characteristic, pathological invasive behaviour of these cells. FLS were obtained during joint replacement sur...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2010
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2010.92